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KMID : 1145520170030020085
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Journal of Radiopharmaceuticals and Molecular Probes
2017 Volume.3 No. 2 p.85 ~ p.90
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Fully automated radiosynthesis of [68Ga]edotreotide ([68Ga]DOTA-TOC) and its quality controls
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Park Hyun-Sik
Lee Hong-Jin
An Hyun-Ho
Moon Byung-Seok
Lee Byung-Chul
Lee Won-Woo
Kim Sang-Eun
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Abstract
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68Ga-PET is of growing importance in the practice of nuclear medicine diagnostic imaging for neuroendocrine tumors as well as prostate cancers. Following this interests, we herein present the radiosynthesis process of [68Ga]edotreotide ([68Ga]DOTA-TOC) based on the fully automated procedure for clinical doses that can be provided the reduction of radiation exposure and high reproducibility. The quality controls of clinical doses in compliant with European Pharmacopoeia are also discussed.
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KEYWORD
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Gallium-68, [68Ga]DOTATOC, [68Ga]Edotreotide, Neuroendocrine tumor
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